Molecular Defects Underlying the Kell Null Phenotype
نویسندگان
چکیده
منابع مشابه
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.
Development of red blood cells requires the correct regulation of cellular processes including changes in cell morphology, globin expression and heme synthesis. Transcription factors such as erythroid Kruppel-like factor EKLF (Klf1) play a critical role in erythropoiesis. Mice lacking EKLF die around embryonic day 14 because of defective definitive erythropoiesis, partly caused by a deficit in ...
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15 صفحه اول21-P026 Molecular analysis of the muscle phenotype of Noggin null mice
functions. However, the mechanisms of GABAergic neurogenesis in the midbrain are not well understood. Previously, it has been shown that Ascl1 is required for development of GABAergic neurons in the midbrain. Here we have characterized in more detail the role of Ascl1 in the development of distinct subpopulations of midbrain GABAergic neurons. In Ascl1-null mutants GABAergic neurons are complet...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m103433200